Synthesis of Substituted Pyrroles via Copper-catalyzed Cyclization of Ethyl Allenoates with Activate

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Substituted pyrroles are structure units of many natural products,synthetic pharmaceuticals and organic conducting materials.Several isocyanides based pyrrole syntheses were acheved by 1,3-dipolar cyclization with alkynes under the catalysis of copper,1 silver2 or phosphine.
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