In current drug discovery pipeline, in vitro biochemical and cell-based screening assays have been widely used before the pharmacological validation tests on in vivo animal models.Nevertheless, the lo
杜氏肌营养不良症是一种X连锁隐形遗传性疾病,大约3,600个男孩中就会有1个患者。临床特点为进行性对称性肌无力,通常在12岁左右失去行走能力,二十几岁死亡。目前临床上尚无法治愈。本讲演将讨论治疗新进展,有些疗法已经在临床上试用,有的还尚在研究中,这些新疗法给杜氏肌营养不良症带来了希望,甚至有治愈的可能。
Chronic neuropathic pain is a common and debilitating consequence of spinal cord injury (SCI).In a rat contusion injury model, we observed that chronic neuropathic pain is present on day 7 after SCI a
Suppressor Of Cytokine Signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway.SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling and inflammatory gene expre
Introduction: The main characteristic of the heat stress response is activation of hypothalamicpituitary-adrenal (HPA) axis, which will promote body to produce cortieotropin releasing hormone (CRH), c
Introduction: The hypothalamic-pituitary-adrenal axis is a key component of the acclimatory response to stress, resulting in the release of stress hormone (CRH)、 cortisol (Cor、 (EPI) and (HSP).CRH can
One of the most pivotal questions in neuroscience is how neurons contribute to neuronal circuitry that mediates brain function.However, most techniques employed now are not powerful enough to sovle th
Early life stress exerts long-term negative effects on emotion, learning and memory and adult sexual behavior.These deficits most likely impair pair bonding.Using socially monogamous mandarin voles (M
The present study to explore the inhibition function in selective attention of anxious individuals, by using the modified negative affective priming paradigm, the event-related potential technology an
γ-aminobutyric acid GABAergic neurons are important elements of the neuronal circuitry in the spinal dorsal horn and play crucial roles in the modulation of nociception.In the present study, we used g