Objective Doxorubicin (Dox) is an anthracycline antitumor antibiotic and is one of the most potent drugs against a wide range of tumours.Cardiotoxicity is an impediment to the clinical use of Dox.Among possible mechanisms o fdoxorubicin-induced cardiotoxicity,oxidative stress has been considered to play an important role.Metallothionein (MT) is a low-molecular weight, cysteine-rich, metal-binding protein.Under a range of pathological conditions, MT functions as a potent scavenger of reactive oxygen species (ROS).