环境双响应型核靶向纳米基因载体的制备与研究

来源 :2015年全国高分子学术论文报告会 | 被引量 : 0次 | 上传用户：killeverrui

【摘要】

：

肿瘤干细胞是引起肿瘤增殖、转移的关键性因素,但由于肿瘤干细胞常处于休眠状态,这使得通过基因治疗对肿瘤干细胞进行杀伤变得十分困难。为了制备一种对于休眠细胞具有高效转染效率的纳米基因载体,我们合成了一种R8 多肽修饰的阳离子聚合物：聚乙烯咪唑-(聚天冬氨酸-胱胺-R8 多肽)-胆固醇(PVIm-(PAsp-Cystamine-R8)-Cholesteryl,PPCRC),以此制备环境双响应型核靶向纳米

【作者】

：

杨哲高锦标李颖琴陈雅刘杰帅心涛陈永明

【机构】

：

中山大学工学院,广州510006 中山大学化学与化学工程学院,广州 510275

【出处】

：

2015年全国高分子学术论文报告会

【发表日期】

：

2015年7期

【关键词】

：

pH和还原双响应核靶向电荷翻转纳米基因载体肿瘤干细胞

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环境双响应型核靶向纳米基因载体的制备与研究

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