Abnormal homeostasis of bivalent metals in Alzheimer's disease

来源 :2nd International Neural Regeneration Symposium(INRS2012)(第二 | 被引量 : 0次 | 上传用户:fsongyifa
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Accumulation of brain amyloid-β is a pathological feature of Alzheimers disease.Dyshomeostasis of bivalent metals such as zinc, iron and copper initiate amyloid-β deposition and the formation of senile plaques.
其他文献
To demonstrate the clinical characteristics of glutaric acidemia type Ⅰ, in terms of its development and prognosis, we followed an 11-year-old patient who was diagnosed as glutaric acidemia type Ⅰ whe
Hyperactivated or impaired microglial cells exert neurotoxic effects involved in the pathogenesis of neurological diseases.The present study first characterized cobalt chloride-induced microglial acti
3beta-hydroxysteroid-delta24 reductase (DHCR24) is a multifunctional enzyme with anti-apoptotic and cholesterol-synthesizing activities and localizes to endoplasmic reticulum.
Stressful experiences, especially psychological stress, can precipitate depression disorder, which is a common public health problem.Accumulating evidence implicates hippocampal neurogenesis in the pa
Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates synaptic plasticity and is related to control of emotion and other central nervous system functions.
The complete cDNA sequence of a novel gene, spinal cord injury and regeneration related gene No.69 (SCIRR69) obtained by RACE, encodes a 521 amino acid protein homologous to human CREB3I2 (BBF2H7) and
This study aimed to investigate the efficacy and safety of oxcarbazepine tablet treatment of children with partial epilepsy.A total of 118 patients, who were 2-14 years old and newly diagnosed with pa
Transient global ischemia induces selective neuronal death in the CA1 area of the hippocampus and Amaurosis fugax, a phenomenon of a transient monocular visual loss.
This study aimed to observe the therapeutic effect of histamine 3 receptor antagonists in an animal model of neonatal hypoxic-ischemic encephalopathy, established in neonatal Wistar rats by ligation o
This study investigated the mechanisms of erythropoietin (Epo) and C-Epo, as neuroprotective treatments for stroke to determine the future clinical use of Epo and C-Epo.A total of 56 male mice were di