Objective Circular RNAs(circRNAs)play important roles in the progression of cancers,but the precise role of circRNAs in the diagnosis and prognosis of hepatocellular carcinoma(HCC)remains to be clarif
Objective DNA-repair pathway genes play an important role in the etiology and progression of breast cancer.BRCA1/2,along withPALB2,CHEK2,andRECQL,is the most commonly mutated genes in hereditary breas
Objective The half-life of Cyclin D1 is about 30 minutes,which is under the tightly control of ubiquitin-proteasomal degradation mechanism during cell cycle progression.
Objective Gastric cancer(GC)is the fifth most common malignancy in the world,especially in developing countries.GC has been the leading cause of cancer death worldwide until the mid-1990s,after which
Objective Purpose: The failure of cancer chemotherapy is mostly caused by the development of drug resistance.In addition to the extensive genetic and epigenetic alterations in cancer cells,cancer cell
Objective While long noncoding RNAs(lncRNAs)have been reported to play an important role in regulating the pathological process of several human cancer types,they remain poorly understood in papillary
Objective Liver cancer is the fourth cause of cancer death worldwide in 2018,with about 841,000 new cases and 782,000 deaths annually.Hepatocellular carcinoma(HCC)comprises 75%-85%of primary liver can
Objective Background: Chemo-resistance remains a major challenge for the successful treatment of breast cancer(BCa),and greatly affects clinical outcomes and overall survival in BCa patients.