Simultaneous detection of multiple biomarkers might lead to improved diagnostic performance for Mycobacterium tuberculosis infection.In this study,we screened soluble biomarkers that had significant d
Objectives:T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cell responses and induction of peripheral tolerance.In this study,the associati
Background:Human immunity-related GTPase M (IRGM) is found to play an important role in defense against intracellular pathogen Mycobacteriurn tuberculosis in vitro by regulating autophagy.To verify wh
To understand the relationship between mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene and drug resistance to ofloxacin,85 laboratory-selected ofloxacin-resistant Myco
The situation of tuberculosis (TB) is very severe in China.New therapeutic agents or regimens to treat TB are urgently needed.In this study,Mycobacterium tuberculosis-infected mice were given immunoth
目的：了解流行毒株核蛋白和糖蛋白的基因特征，并对流行毒株与疫苗毒株的核蛋白和糖蛋白的基因序列进行比较分析。方法：分别采用直接免疫荧光(dFA)和巢式RT PCR方法检测狂犬病病例和宿主动物标本的病毒抗原和核酸，对病毒核酸阳性标本进行核蛋白和糖蛋白基因序列测定和拼接，并结合已发表疫苗毒株基因序列对流行毒株与疫苗毒株基因序列进行比较分析。结果：贵州省狂犬病病毒流行毒株均属基因1型，但在核蛋白和和糖蛋白
狂犬病疫苗的发展具有悠久而灿烂的历史,早于人们了解病毒及其致病和免疫机制。正确应用细胞培养来源的灭活疫苗,可以非常有效地预防狂犬病的发病,鲜有失败案例的报道。此外,也可以对野生动物,宠物和家畜进行口服和注射接种细胞培养来源的疫苗。然而,狂犬病在世界的许多地区仍然流行,每年导致成千上万的人死亡。原因是,一旦病毒进入中枢神经系统(CNS),则没有办法阻止狂犬病的发生。另一个原因是,CNS对狂犬病毒的免