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精氨酸加压素（ＡＶＰ）的Ｃ端内片段，ＡＶＰ（４－８），具有增强记忆的功能，它在大鼠脑内引发一系列的生理和生化变化。ＧＴＰ－结合调节蛋白（Ｇ蛋白）介导多数神经肽和神经调质的细胞内生理生化反应。放射性受体结合实验显示，在海马突触膜上存在ＡＶＰ（４－８）的特异性结合位点。ＡＶＰ（４－８）在海马突触膜上的结合能够进一步刺激ＧＴＰγＳ结合并可被ＡＶＰ（４－８）的受体拮抗剂ＺＤＣ（Ｃ）ＰＲ所逆转。从以上实验结果可以认为ＡＶＰ（４－８）是通过海马突触膜上的Ｇ蛋白偶联受体来发挥其神经调质作用的。
AVP (4-8), a C-terminal fragment of arginine vasopressin (AVP), has a memory-enhancing function that triggers a series of physiological and biochemical changes in the rat brain. GTP-binding regulatory proteins (G proteins) mediate the intracellular physiological and biochemical reactions of most neuropeptides and neuromodulators. Radioactive receptor binding experiments show that there is a specific binding site for AVP (4-8) on the hippocampal synaptic membrane. Binding of AVP (4-8) to the hippocampal synaptic membrane further stimulated GTPγS binding and was reversed by the receptor antagonist ZDC (C) PR of AVP (4-8). From the above experimental results, it is considered that AVP (4-8) exerts its neuromodulatory effect through a G protein-coupled receptor on the hippocampal synaptic membrane.