survivin是凋亡抑制蛋白家族成员之一,具有很强的抑制凋亡的作用。近年来survivin在胰腺癌中的表达、与临床病理及预后的关系以及在放化疗耐受上的作用均有研究报道,并有可能成为胰腺癌基因靶向治疗的靶点之一。本文复习相关文献,就survivin在胰腺癌中的研究进展作一综述。 Survivin is a member of the apoptosis-inhibiting protein family and has a strong inhibitory effect on apoptosis. In recent years, the expression of survivin in pancreatic cancer, the relationship with clinicopathology and prognosis as well as the role of radiotherapy and chemotherapy resistance have been reported, and may become one of the target of pancreatic cancer gene therapy. This review of relevant literature, the progress of survivin in pancreatic cancer are reviewed.