【摘 要】
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Optimal T-cell activation requires both an antigenspecific and a costimulatory signal.CD167 is a tyrosine kinase receptor for native type Ⅰ collagen,its physiologic functions include matrix homeostasi
【机 构】
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Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology
【出 处】
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全军免疫学第七届学术交流会暨免疫学新进展主题论坛
论文部分内容阅读
Optimal T-cell activation requires both an antigenspecific and a costimulatory signal.CD167 is a tyrosine kinase receptor for native type Ⅰ collagen,its physiologic functions include matrix homeostasis and cell growth,adhesion,branching,and migration,but the specific role of CD167 in T cells has not yet been characterized.In this study,we found that CD167 expression on T cells was up-regulated after activation.Cooperation of CD167 engagement with suboptimal TCR/CD3 signals induced T-cell proliferation,enhanced expression of activation markers such as CD25 and CD69,elevated intracellular calcium mobilization and tyrosine phosphorylation,and introduced a bias toward a TH1/Tc1 immune response.
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