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Introduction: Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans.However,the procedure for culturing the traditional 21-day Caco-2 model is labor intensive and time consuming,which limits its wide application in drug development.The objective of the present study was to develop a rapid Caco-2 model with 7-day cell culture process.