【摘 要】
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Neuropeptide S receptor display widespread locatization in the central nervous system[1],and the NPS/NPSR system,potently modulates wakefulness,anxiety,arou
【机 构】
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KeyLaboratoryofPreclinicalStudyforNewDrugsofGansuProvince,InstituteofBiochemistryandMolecularBiology
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Neuropeptide S receptor display widespread locatization in the central nervous system[1],and the NPS/NPSR system,potently modulates wakefulness,anxiety,arousal,locomotion,food intake,memory,and drug addiction.NPSR activation will increases in intracellular calcium levels[2].Structure–activity studies[3] demonstrated that :(1)The NPS(1–10)fragment is the shortest to remain the fuction of activate NPSR,and the C-terminal 11–20 sequence is necessary for its in vivo biological effects.
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