Streptomyces coelicolor is the most intensively studied and a model member of the genus Streptomyces,and the number of genes encoded in its genome is among the highest of any bacterium known to date [1].During cultivation,a culture of S.coelicolor undergoes a comprehensive metabolic rearrangement in response to environmental changes (e.g.nutrient limitation),leading to a transition froth growth to secondary metabolite production phase.This transition is assumed to be controlled by a complex regulatory network rather than by individual global regulators [2].The SysMO (STREAM)project heads for a detailed molecular understanding and characterization of this regulatory network by a systems biology approach involving combination of full-scale omics analysis of high timeresolution samplings,and mathematical modelling.