Glia cells are regarded as a mediator of neuroinflam mation releasing proinflammatory cytokines and nitric oxide in the central nervous system.Microglia and astrocytes have been reported to play an important role in the progression of neurode generative diseases such as Alzheimers disease and Parkinsons disease.m-Chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mecha nisms of actions are not well understood.