Background: Recently,the prediction of gene function has become a hot issue and various methods have been used to predict system-levels function of genes.Within those feasible methods,gene co-expression networks,as intuitive network concepts (e.g.connectivity and module) have been found to be useful for analyzing complex interactions and turn out to be more predictive and efficient.In previous study,the gene co-expression network analysis contributed to the prediction of gene function by Go-Labels.