Synthesis and Cardioprotective Effects of Novel Danshensu Analogues

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户:woyaoguo_sanji
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  Danshensu(DSS),the water-soluble active component of Danshen,is the main constituent responsible for many of Danshens biologic activities including cardioprotective properties in various experimental models.However,its intrinsic problems such as poor chemical stability,low potency and inadequate therapeutic efficacy restrict its further applications.Therefore,it is necessary and essential to make chemical modifications to improve its stability and especially pharmacological activity.
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