论文部分内容阅读
Several studies have evaluated the risk factors influencingthe biochemical recurrence (BCR)in patients who have received salvage radiotherapy (SRT) for BCR after radical prostatectomy (RP), but the results remain conflicting.In this study, we performed a meta-analysis to resolve this conflict.Twelve studies,including a total of 1472 patients were included in our meta-analysis.Of all the variables, Gleason score (GS)≥ 7(odds ratio (OR): 2.59;95% confidence interval (CI):1.24-5.40);Pathological tumor (pT) stage ≥ pT3a (OR: 1.87;95%CI: 1.08-3.23) were in positive correlation with BCR.However, SRT combined with androgen deprivation therapy (ADT) (OR: 0.58;95%CI: 0.42-0.82) and radiation therapy (RT) dose ≥ 64Gy (OR: 0.35;95%CI: 0.19-0.64) were in negative correlation with BCR.Additionally, perineural invasion (OR:3.91;95%CI: 0.85-17.93), preoperative PSA ≥ 10ng/ml (OR: 1.40;95%CI: 0.99-1.97), positive surgical margin (OR: 1.09;95%CI: 0.84-1.42) and Seminal Vesicle Involvement (SVI) (OR: 0.99;95%CI:0.62-1.57) has no effect on BCR.Our meta-analysis indicated that pT stage, GS, RT dose and SRT combined with ADT may be factors influencing BCR;while preoperative PSA, surgical margin, perineural invasion and SVI have weak effect on BCR.