【摘 要】
：
Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases,including liver fibrosis.Our previous studies have demonstrat
【机 构】
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DepartmentofCellBiology,MunicipalLaboratoryforLiverProtectionandRegulationofRegeneration,CapitalMedi
【出 处】
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首都医科大学第四届研究生学术论坛第二分论坛
论文部分内容阅读
Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases,including liver fibrosis.Our previous studies have demonstrated that after liver injury,mouse bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to the injured liver and differentiate to myofibroblasts,contributing to hepatic fibrogenesis.However,the role of CBs in the homing of BMSCs in liver injury is yet unclear.In this study,we found that both CB1 and CB2 were expressed in BMSCs.Migration assays were performed by transwell chambers.CB1 agonist ACEA promoted the migration of BMSCs,but CB2 agonist JWH133 had no effect.Pharmacological or genetic ablation of CB1 reduced ACEA-induced migration,whereas CB2 did not.
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