HYPOCHLOROUS ACID, A MACROPHAGES PRODUCT, INDUCES ENDOTHELIAL APOPTOSIS:THE ROLE OF ENDOPLASMIC RETI

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:zhouqiuhe1
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objectives Superficial erosion of coronary plaques due to endothelial loss causes acute coronary syndromes (ACS).Hypochlorous acid (HOCl), a macrophages product can induce endothelial apoptosis.Disturbing (ER) function results in ER stress and unfolded protein response, which tends to restore ER homeostasis but switches to apoptosis when ER stress is prolonged.Therefore, we aimed to investigate whether prolonged ER stress is induced by exogenous HOCl and its underling mechanisms.
其他文献
Objectives To create a model of minicking VAD by unloading rats with HF (heart failure) after dilated cardiomyopathy in rats.Methods Heart failure (HF) was induced by the intraperitoneal administratio
会议
Objectives Tanshinone ⅡA, one of the active ingredients in danshen, which derived from the dried root or rhizome of Salviae miltiorrhizae BGE, is cardioprotective when applied before myocardial sustai
会议
Objectives Heart failure is the leading cause of death in patients with chronic kidney disease (CKD).Advanced oxidation protein products (AOPPs) induced microvascular pathology and contributed to the
会议
Objectives To explore the effect of c-met overexpression in EPCs on reendothelialisation after balloon injury.Methods EPCs derived from mouse bone marrow were isolated and cultured.3-(4,5-dimethylthia
会议
Objectives To study the effects of rosuvastatin on C reactive protein (CRP)-induced inflammatory factors expression in endothelial outgrowth cells (EOCs).Methods Mononuclear cells (MNCs) were isolated
会议
Objectives Several studies have demonstrated coagulant system was activated after transcatheter closure of ASD, but changes of platelet function still remain controversial.Currently, it is not clear w
会议
Objectives To investigate the potential beneficial effect of Bosentan in ameliorating fibrotic agents in diabetic mice.Methods Male C57BL/6 mice with 6-week old were divided into 3 groups (N =20) : Co
会议
Objectives Aortic valve interstitial cells (AVICs) play a vital role in the development of aortic valve stenosis.The aim of this study is to observe that whether or not AVICs calcified spontaneously a
会议
Objectives The purpose of this study was to compare two scoring systems used for diagnosis of acute mountain sickness (AMS): Lake Louise Scoring (AMS-LLS) and Chinese Scoring System (AMS-CSS).Methods
会议
Objectives CYP4F2 is responsible for metabolising arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the regulation of cardiovascular homeostasis.The present
会议