Cancer progression involves carcinogenesis, an increase in tumour size, and metastasis.Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL 14/BRAK (CXCL 14) transgenic (Tg) mice.The rate of AOM/DS S-induced colorectal carcinogenesis in these mice was significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice.When tumour cells were injected into these mice, the size of the tumours that developed and the number of metastatic nodules in the lungs of the animals were always significantly lower in the Tg mice than in the Wt ones.