Herb-drug interactions are an important issue in drug safety and clinical practice.The aim of this study was to charac terize epidemiological profiles in schizophrenic patients, particu larly associat
Problems with sleep are becoming more and more pronounced in moderu societies.Difficulties formulating compre hensive approaches to treat sleep-related diseases persist because the physiological mecha
OBJECTIVE To investigate whether GLE exerts its hypnotic effect in freely moving rats and the possible mecha nism METHODS GLE was extracted from fruiting bodies of G.lucidum.TNF-α level was measured b
The impairment of baroreflex control of heart rate (HR) was examined and structural remodeling of cardiac ganglia was assessed in the streptozotocin (STZ)-induced diabetic mouse model.FVB mice were ei
OBJECTIVE To investigate the interactions be tween diltiazem and two kinds of serotonin receptors (5-HT1A,5-HT2A/2C) and examine the c-fos expression of serotonergic neu rons in DRN in pentobarbital t
OBJECTIVE Many studies support an important role of GABA in the sleep-wake cycle.GABA transporter sub type 1 (GAT1) constructs high affinity reuptake sites in the CNS and regulates GABAergic transmiss
目的 对酮酸显色法检测DAO酶活性的条件进行改进,以建立适合筛选大鼠脊髓DAO抑制剂治疗疼痛的方法。方法 大鼠脊髓粗提液与底物D型丙氨酸反应后加三氯乙酸终止反应,上清液先与酸化的2,4-二硝基苯肼反应,再碱化显色后于450 nm测定吸光度值以计算脊髓D型氨基酸氧化酶(DAO)酶活力。为确定最佳条件,酶粗提液首先与过量底物反应,选取反应未饱和但显色明显的时间点作为合适反应时间；之后测定在此时间内脊髓
OBJECTIVE To specifically looking at the NAc striatum connection in human drug addicts.METHODS In to tal 23 heroin addicted and 15 control subjects were scanned in a 3T GE scanner with TR =2000 ms, TE
OBJECTIVE To explore role of the brain area as modulator and the underlying mechanism of the diurnal variation of cocaine reward.METHODS We examined the circadian rhythm of GSK-3β activity in SCN and
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse.For this reason, the identification of medications that prevent drug relapse is a criti cal goal of drug