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目的:通过家兔模型,探讨艾叶多糖预防乙酰氨基酚诱导肝中毒的临床机制。方法:比色法测定不同时间点对乙酰氨基酚浓度;己糖激酶法(GLUHK)测定血糖浓度。结果:提前注射艾叶多糖可以前移家兔体内对乙酰氨基酚的吸收峰和吸收时间点,以2h最明显,且吸收峰值与血糖值高度相关;与未注射艾叶多糖家兔相比较,有显著差异(P<0.01)。结论:艾叶多糖可预防乙酰氨基酚肝中毒,作用机制可能与艾叶多糖升高血糖浓度而使肝细胞能量增加,以及提供较多还原性辅酶II和还原性谷胱甘肽有关。
OBJECTIVE: To investigate the clinical mechanism of the prevention of acetaminophen-induced hepatotoxicity by wormwood polysaccharides through a rabbit model. Methods: The colorimetry was used to determine the concentration of acetaminophen at different time points; the hexokinase method (GLUHK) was used to determine the blood glucose concentration. RESULTS: The pre-adsorption of wormwood polysaccharide could advance the absorption peak and absorption time point of acetaminophen in rabbits, which was the most obvious at 2h, and the absorption peak was highly correlated with the blood glucose level. Compared with uninjected wormwood rabbits, there was significant difference. Difference (P<0.01). Conclusion: Alfalfa polysaccharide can prevent acetaminophen hepatotoxicity, and the mechanism may be related to the increase of hepatocyte energy by increasing the blood sugar concentration of wormwood polysaccharides, and providing more reducing coenzyme II and reducing glutathione.