Epidermal growth factor-like domain protein 6 (EGFL6) is a member of the epidermal growth factor-like (EGFL) protein family, which involves in a number of physiological processes including regulation of cell adhesion and angiogenesis,promotes proliferation and migration of vascular endothelial cells;EGFL6 is over-expression in some tumor tissues, such as lung cancer, melanoma and ovarian cancers, and it suggests that it may play an important role in the development of cancer and may become a new target for cancer diagnosis and treatment.