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Epoxyeicosatrienoic acids (EETs),metabolites of arachidonic acid (AA),are known to have anti-inflammatory effects and hydrolyzed by soluble epoxide hydrolase (sEH).We aimed to investigate the effect of sEH inhibition on atherosclerotic progression.LDLR-/- mice with or without sEH inhibitor and LDLR and sEH double knockout (DK) mice were fed with western diet for 6 weeks to induce arteriosclerosis,and then half of the mice switched to chow diet supplemented with sEH inhibitor for another 6 weeks.