Schizophrenia etiology is thought to involve the interaction between genetic and environment factors during brain development.Despite significant progress in understanding both genetic susceptibility and neuronal circuit dysfunction in schizophrenia,fundamental gaps exist in how circuitry mechanisms may interact with genetic susceptibility to affect neuronal development.DISC1 is a susceptibility gene for major mental disorders and has been shown to regulate a number of neural developmental processes during adult hippocampal neurogenesis,including cell proliferation,newborn neuron morphogenesis,dendritic development,and synapse formation.Our recent studies have further shown that loss of function of DISC1 in young adult-born neurons in the mouse hippocampus is sufficient to cause affective and cognitive defects.Using electrophysiological and imaging approaches,we found that DISC1 dysfunction in adult-born neurons initially leads to aberrant GABAergic and glutamatergic synaptic inputs.And our results suggest distinct neuronal circuit interacts with the genetic susceptibility to affect different aspects of aberrant neuronal development.