论文部分内容阅读
Recently studies have demonstrated the association between Aspirin and brain tumour risk.However,results from these studies have been inconsistent.The objective of this metaanalysis is to summarize the evidence on this association.A comprehensive search for articles published up to July 2014 was performed.Five Studies published between 2003 and 2013,were included in this analysis.Compared with non-aspirin use,overall use of aspirin was not statistically significantly associated with brain tumour risk based on the random-effects models(RR = 0.94; 95%CI = 0.88-1.00; P = 0.04).However,our analysis found a slightly increased risk of brain tumour between low-dose aspirin and high-dose aspirin(RR = 0.71; 95%CI = 0.65-0.80; P < 0.001).This study revealed that use of aspirin and non-aspirin NSAIDs does not appear to be associated with brain tumour risk,but larger studies are needed to substantiate the association between frequency and dose gender of aspirin use and brain tumour risk