Introduction.Sensitive skin represents a subclinical phenominea characterized by a series of symptoms such as itching, burning and stinging and so on.Many studies have been carrried out on the machnism, pathologic process and the detecting techniques of sensitive skin.TRPV-1 (Transient receptor potential channel, vanilloid subfamily member 1) could be activited by casaicin and induce skin burning sensation, which indicated that this receptor may be involved in human sensitive skin.