The synthesis and design of biologically active molecules in a single operation without isolation of intermediates is the main challenges in medicinal chemistry1.
Over the past several years,C-H bond functionalization has attracted considerable attention for its outstanding advantages in atom efficiency and synthesis step efficiency compared to traditional cros
Quinolizine and its derivatives is an important kind of alkaloid,which is widely existed in the natural compounds and pharmaceutically significant substances.
Pyrazoles constitute an important class of heterocyclic compounds exhibiting a wide range of biological activities[1] and they also act as vital building blocks of many pharmaceuticals and natural pro
质谱技术具有灵敏度高、特异好、普适性强等特点越来越成为最受青睐的现代分析测试技术之一.江西省质谱科学与仪器重点实验室研发的电喷雾萃取电离技术(EESI)[1]无需样品预处理即可以直接进行质谱分析,且数据重复性好,能够满足多变量统计分析的需要;此外,其电离区的独特设计也避免了待测物分子与高强电场的直接接触,是比ESI 更软的离子化方法,故利用EESI-MS 能够原位监测捕捉到有机反应过程中的反应物、
由于核磁共振波谱检测具有方便、简单、快速、环境友好等优点,同时随着小型化、微型化核磁共振的发展和普及,基于NMR 方法的手性识别及ee 值的测定越来越受到化学家的青睐[1],它能够观测到手性分子中每一个功能基团在手性识别过程中的表现,能清晰地表明主客体相互作用的位点,并且可以预测非对映体络合物的空间构象.一般说来,NMR 主要借助于化学位移、耦合常数、弛豫时间、NOE、扩散系数等参数来研究手性识别
As the CF3 group plays a conspicuous and increasingly important role within pharmaceuticals and agrochemicals,as well as in materials science,there has been a great deal of interest in developing effi
合成一系列50 种含C=N 桥键的芳基希夫碱对位-二取代苯亚甲基苯胺化合物p-X-C6H4CH=NC6H4-p-Y,测定其C=N 键的红外伸缩振动频率VC=N.
Density Functional Theory(DFT) at IDSCRF-B3LYP/DGDZVP computational level is employed to conduct theoretical study about reaction between o-carborane(R1a),n-butyllithium and N,N-diisopropylcarbodiimid
The infection disease caused by bacterial pathogens has become a major public health problem in recent years due to wide occurrence of drug resistance.