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Phthalimidine (isoindolin-1-one) and its derivatives have attracted considerable interest due to their fascinating properties and great potential applications in the fields of biology,medical science and organic synthetic chemistry.The recent elaboration has proven that the phthalimidino group plays a key role in the pharmacological activity of correlated synthetic and natural compounds.The new phthalimidine derivative with unique biological activity might be a precursor of efficacious drug for therapeutic and prophylactic use,such as antipsychotics,hypolipidemic and antimicrobial.In this work,a histidine-containing Phthalimidine derivative 2-(1-oxo-1H-2,3-dihydroisoindol-2-yl)-3-imidazolyl-L-lactamic acid (1) was successfully synthesized by a simple procedure.Its structure was characterized by elemental analysis,IR,NMR,and single crystal X-ray diffraction study.Luminescence,nonlinear optical property,as well as in vitro antibacterial and antifungal activities of the compound were discussed.