Objective: This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis.Methods: The major databases were searched from the databases inception through November 2014.Randomized controlled trials of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers.The RCTs examined included total efficacy rate and biochemical indices including ALT, AST, TBIL and DBIL.The Cochrane tool was applied to assess the risk of bias of the trials.The main outcomes of the trials were analyzed using Review Manager 5.3 software.The odds ratio or mean difference with a 95% confidence interval was used to measure the effect.Results: Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis.Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not.Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods.Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease.No serious adverse event was reported.Conclusion: This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis.