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The A-type lamin deficient mouse line (Lmna-/-) has become one of the most frequently used models for providing insights into many different aspects of A-type lamin function.To elucidate the function of Lmna in the growth and metabolism of mice,tissue growth and blood biochemistry were monitored in Lmna-deficient mice,heterozygous (Lmna+/-) and wide-type (Lmna+/+) backcrossed to C57BL/6 background.