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Objective To evaluate the effects and safety of 300-600mg of alpha lipoic acid (ALA) given intravenously for diabetic peripheral neuropathy.Methods Electronic database searching was performed on Medline,Embase,Cochrane Library and Chinese Biological Medicine (CBM).Randomized controlled trials (RCTs) concerning the treatment with alpha lipoic acid for diabetic peripheral neuropathy (DPN) were selected and assessed for the methodological quality.