Autophagic lysosome reformation (ALR) plays important role in maintaining lysosome homeostasis.During ALR,lysosomes are reformed by recycling lysosomal components from autolysosomes.The most visible s
Rutile phase titania nanoneedles were deposited on the surfaces of the anatase phase titania nanotubes templated by natural cellulose substance by a hydrothermal process,giving a hierarchical structur
驱动蛋白颈链向马达头部的对接是驱动蛋白力产生的过程,此对接过程是通过颈链和马达头部之间的各种非键相互作用实现的。之前的研究结果发现,颈链的ASN334与马达头部的GLY77形成一条骨架氢键,此骨架氢键周围存在三个疏水氨基酸,这三个疏水氨基酸之间具有疏水相互作用,此结构被称为ASN latch,具有很高的强度。我们发现ASN latch高强度来源于疏水相互作用和氢键相互作用的配合。以ASN334与G
Eight novel lanthanide complexes [Ln(3,4-DC1BA)3phen]2 (Ln=Ho(1),Nd(2),Sm(3),Dy(4),Eu(5),Tb(6),Yb(7),Er(8),3,4-DC1BA=3,4-dichlorobenzoic acid,phen=1,10-phenanthroline) were prepared.All of thcm were c
Interplay of secondary and tertiary structural formations as significant folding events is crucial for the folding progresses of proteins.Here,we performed independent MD simulations on the wild-type
The activity,structure and related function of key enzymes-[FeFe]-hydrogenase is discussed in this paper,which capable of catalyzing the molecular hydrogen for dissociating H2,or generating the revers
The crystal structure of complexes of [Tb(3-Br-4-MBA)3phen]2(1),[Ho(3-Br-4-MBA)3(phen)H2O]2(2),[Er(3-Br-4-MBA)3(phen)H2O]2(3) have been solved by single-crystal X-ray diffiaction methods.The complex 1
Genetically encoded calcium biosensors are valuable tools in cell biology and neuroscience.A FRET-based calcium biosensor Cameleon has received a great deal of optimization since it was released in 19
Tetraphenylethylene (TPE),an archetypal luminogen with aggregation-induced emission (AIE),was grafted to a salt-responsive peptide to yield a yet luminescent hydrogelator.After testing different param
Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides