Design of a Novel Peptidic HIV-1 Fusion Inhibitor Against Drug-Resistant Viruses

来源 :2006中国天津世界艾滋病日科技会议 | 被引量 : 0次 | 上传用户：dabing_12130

【摘要】

：

【作者】

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Jianwei Cheng Yuxian He Mingxin Dong Hong Lu Shuangshuang Hou Jingling Li Shibo Jiang Qiuyun Dai

【机构】

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Beijing Institute of Biotechnology,Beijing 100071, China

【出处】

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2006中国天津世界艾滋病日科技会议

【发表日期】

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2006年12期

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　　Background:Enfuvirtide (T20),a fusion inhibitor derived from the C-terminal heptad repeat region (CHR) of HIV-1 gp41 is the only peptidic anti-HIV drug licensed by the US FDA.However,concerns have been raised over the increasing failure rate of therapy due to emergence of T20-resistant viruses in the treatment-experienced AIDS patients.Therefore,development of novel anti-HIV drugs against T20-resistant variants remains of high importance.

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Design of a Novel Peptidic HIV-1 Fusion Inhibitor Against Drug-Resistant Viruses

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