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目的:观察温阳散寒法配合化疗治疗中晚期肺癌的疗效。方法:将50例患者随机分为两组。治疗组25例,采用温阳散寒法基本方药联合化疗;对照组25例,单纯用化疗。结果:近期疗效有效率治疗组为64%,对照组为56%,2组比较,差异不显著(P=0.56>0.05)。生活质量karnofsky(KPS)评分总有效率治疗组为80%,对照组为44%,两组比较,差异有显著性意义(P=0.009<0.01)。毒副反应方面:治疗组骨髓抑制发生率为64.0%,对照组为88.0%,两组有显著差异(P<0.05);恶心呕吐发生率:治疗组为92.0%,对照组为96.0%,两组无显著性差异(P>0.05)。1年生存率比较治疗组为64.0%(16/25),对照组为40.0%(10/25),两组间有显著性差异(P<0.05)。结论:温阳散寒法配合化疗治疗中晚期肺癌,有提高患者1年生存率,减轻毒副反应,提高生活质量的作用。
Objective: To observe the curative effect of warming Yang and dispersing cold therapy combined with chemotherapy on advanced lung cancer. Methods: 50 patients were randomly divided into two groups. The treatment group of 25 cases, the use of Wenyang San cold method of basic prescriptions combined with chemotherapy; control group of 25 cases, simple chemotherapy. Results: The effective rate in the short term was 64% in the treatment group and 56% in the control group. There was no significant difference between the two groups (P = 0.56> 0.05). The total effective rate of Karnofsky (KPS) score was 80% in the treatment group and 44% in the control group. There was significant difference between the two groups (P = 0.009 <0.01). Toxicity and side effects: The incidence of bone marrow suppression was 64.0% in the treatment group and 88.0% in the control group, with significant difference between the two groups (P <0.05). The incidence of nausea and vomiting was 92.0% in the treatment group and 96.0% in the control group There was no significant difference between the two groups (P> 0.05). The 1-year survival rate was 64.0% (16/25) in the treatment group and 40.0% (10/25) in the control group, with significant difference between the two groups (P <0.05). CONCLUSION: The method of warming yang and dispersing cold together with chemotherapy in the treatment of advanced lung cancer has the effect of improving 1-year survival rate, reducing side effects and improving quality of life.