Precise quantification of energy transport and heat generation is key to obtaining insights into a wide range of phenomena across various disciplines including engineering,biology,physics and chemistry.This lecture will describe recent advances into heat-flow calorimetry,which enable precise measurement of energy transport at micro and nanoscales with picowatt resolution.Specifically,I will describe two classes of calorimeter devices,which are capable of achieving single digit picowatt resolution at room temperature.Each type of device incorporates two important features: A region that is isolated from the ambient via a weak thermal link with a conductance(GTh~1 μW/K),and a high-resolution thermometer with temperature resolutions(ΔTres)that are in the micro kelvin regime.This enables measurements of heat currents(q)with ultra-high resolution(q= GTh×ΔTres).I will also describe how these calorimeters have been used in conjunction with a novel nanopositioning system to obtain new insights into near-filed radiative thermal transport.