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OBJECTIVE: To investigate the efficacy and safety of tranexamic acid reducing blood loss after total knee arthroplasty.METHODS: We enrolled 64 patients with primary osteoarthritis undergoing a unilateral total knee arthroplasty and randomized them into two groups, with 32 patients in each group.Tranexamic acid group: patients received intravenous drop infusion of tranexamic acid dissolved in 250 mL normal saline (10 mg/kg) at 15 minutes before operation;control group: patients just received 250 mL normal saline.