Design,synthesis and bioactivity of novel diaryl ketone derivatives as potent HIV-1 NNRTIs

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yangxiaoxi21

【摘要】

：

Benzophenone derivatives(BPs),such as GW678248 and GW4511,have been reported as a class of HIV-1 NNRTIs with excellent potency against a broad panel of wild type and resistant mutant strains[1,2].

【作者】

：

Lingzi Zhang Peng Zhan Christophe Pannecouque Xinyong Liu

【机构】

：

Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School o

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

HIV-1 NNRTIs Diaryl ketone Synthesis Anti-HIV-1 activity

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　　Benzophenone derivatives(BPs),such as GW678248 and GW4511,have been reported as a class of HIV-1 NNRTIs with excellent potency against a broad panel of wild type and resistant mutant strains[1,2].

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Design,synthesis and bioactivity of novel diaryl ketone derivatives as potent HIV-1 NNRTIs

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