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目的 MUC1 is a membrane-tethered glycoprotein expressed in various mucosal epithelial cells as well as hematopoietic cells andplays an anti-inflammatory role during the resolution phase of airway bacterial infection.Recently,we showed that the antiinflammatoryeffect of MUC1 is attributable to its cytoplasmic tail,specifically the presence of the EGFR phosphorylation site(YEKV).In this study,we synthesized a compound which consists of an 11-mer peptide of MUC1 cytoplasmic tail containing YEKVand two covalently linked carrier molecules - TAT peptide and palmitic acid - in order to determine whether this compound canexhibit an anti-inflammatory effect in an in vitro inflammation model.So our aim is to see whether this MUC1 mimeticpepticcould suppressed Pseudomonas aeruginosa-induced inflammation and its mechanism study.