【摘 要】
：
Although CD4+Tfh cells are recognized to play an important role in the inflammatory response,the biological functions of CD8+Tfh cells remain unclear.In this study,we analyzed cell markers,cytokine ex
【机 构】
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School of medicine,ChinaThreeGorgesUniversity,Yichang,Hubei,443002
【出 处】
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中国生物化学与分子生物学会2016年全国学术会议
论文部分内容阅读
Although CD4+Tfh cells are recognized to play an important role in the inflammatory response,the biological functions of CD8+Tfh cells remain unclear.In this study,we analyzed cell markers,cytokine expression and transcription factors in IL-21-expressing CD8+T cells in polyp tissues of NP patients.The results showed that the majority of IL-21-producing CD8+T cells were effector memory cells and they co-expressed IFN-γ.IL-21-expressing CD8+T cells in polyp tissues expressed higher CXCR5,PD-1,and ICOS levels than cells in control tissues and showed significantly higher T-bet and Bcl-6 expression levels compared with IL-21-CD8+T cells.Purified polyp CD8+T cells promoted IgG production from isolated polyp B cells in vitro,and recombinant IL-12 modulated the expression of IL-21,IFN-γ and CD40L in purified polyp CD8+T cells.Moreover,the percentage of IL-21+CD8+T cells in polyp tissues was positively correlated with endoscopic and CT scan scores in NP patients.These findings indicated that polyp CD8+T cells,by co-expressing IL-21 and IFN-γ and other markers,display a Tfh cell functionality,which is associated with the clinical characteristics of NP patients.
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