论文部分内容阅读
FUS 是一种RNA 结合蛋白。它可以在细胞内形成功能性的无膜颗粒辅助RNA 行使功能，也会形成病理性聚集导致神经退行性疾病。细胞通过特定位点的丝氨酸/苏氨酸上的磷酸化来调控FUS 的组装形态，并抑制病理性聚集的产生。
定点磷酸化对于FUS淀粉样片段诱导其低复杂度区域从相分离到聚集的调控
【摘 要】
：
FUS 是一种RNA 结合蛋白。它可以在细胞内形成功能性的无膜颗粒辅助RNA 行使功能，也会形成病理性聚集导致神经退行性疾病。细胞通过特定位点的丝氨酸/苏氨酸上的磷酸化来调控FUS 的组装形态，并抑制病理性聚集的产生。
【机 构】
：
生命科学与技术学院,北京化工大学,北京,100029 Department of Chemistr
【出 处】
：
第十一届全国化学生物学学术会议
【发表日期】
：
2019年3期
其他文献
PET imaging of γ-Glutamyltranspeptidase activity in living animals with an activatable fluorine-18 l
Multiple enzymes are usually involved in a given biological process to regulate a variety of diseases including malignancy.
大环超分子荧光探针作为一类重要的荧光探针已经引起了研究者的广泛关注，通过引入特定的大环分子如冠醚、杯芳烃、柱芳烃、环糊精和葫芦脲等，具有特定尺寸、可特异性配合某些基团的性质。
Arylboronic acids and their esters has been widely used in the development of fluorescent probes for the monitoring of different reactive oxygen species(ROS)such as hydrogen peroxide,hypochlorite or p
Protein-protein interactions play vital roles in various biological processes.Compared with other methods,genetically encoded photocrosslinking could convert non-covalent interactions to covalent bond
Quinoline-2,3-dicarboxaldehyde:a special o-dialdehyde fluorescent probe simultaneously sensing Hcy a
Biothiols such as cysteine(Cys),homocysteine(Hcy),and glutathione(GSH)play key roles in biological processes,and the level of each biothiol is considered to be sign of many diseases.
A Cyclometalated Iridium (Ⅲ) Complex which targets Mitochondria for the Highly Efficient Photodynami
Cancer is one of the leading causes of death globally,and the development of anticancer agents is therefore of paramount importance.
适配体(aptamer)是一种能够与相应的靶标物发生高亲和力和强特异性结合的DNA 或者RNA 片段，结合光电化学分析技术，以氧化铟锡(ITO)为基底电极，通过优化ZnO 纳米棒沉积参数及纳米金修饰方法，制备了光敏界面修饰的光电极(Au/ZnO/ITO)。
Antibiotics has added an average of 20 years to our life.Unfortunately,bacteria are resistant to almost all antibiotics.
Ratiometric Fluorescence Imaging of Endogenous H2Sn Revealing its Signaling Pathway in Non-Alcoholic
Hydrogen polysulfides(H2Sn,n > 1)proved to be a crucial reactive sulfur species(RSS)as their key functions in different biological processes were continuously revealed in recent years.
The exploration of RNA methylation was rejuvenated in the second decade of this century with the discovery of FTO as m6A demethylase in cells,which uncovered that RNA methylation is a dynamic and reve