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5. A Novel Method on Next-Generation Data Normalization and Differentially-Expressed Gene Detection

A Novel Method on Next-Generation Data Normalization and Differentially-Expressed Gene Detection

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：descendant_of_shang

【摘 要】

：

Next generation sequencing(NGS)data contain measurement errors.Normalizing NGS data is challenging and crucial.We propose to normalize the NGS gene expression profiles via binning and density estimati

【作 者】

：

Bin Wang 

【机 构】

：

Department of Mathematics and Statistics,University of South Alabama,Mobile,AL 36688,USA

【出 处】

：

上海交通大学

【发表日期】

：

2016年4期

【关键词】

：

Binning Non-parametric Regression Density Estimation Generalized Lambda Distribu 

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　　Next generation sequencing(NGS)data contain measurement errors.Normalizing NGS data is challenging and crucial.We propose to normalize the NGS gene expression profiles via binning and density estimation based on pre-binned data.

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