Cancer is becoming the leading cause of death in China.Our studies revealed that ELMO and Ritor/PKC regulated cancer cell migration and metastasis.Genetic analysis shows heterogeneity in tumors and in metastatic nodules which further complicated the diagnosis and treatment.Using nanotechnology,we combined the efficacy of chemotherapy with photodynamic or sonodynamic therapies,and achieved satisfactory results in mouse models.We propose that,with the aid of nanotechnology,sonodynamic therapies will play an increasing role in cancer treatments with low toxicity and high efficacy.