【摘 要】
：
目的:探讨卒中后抑郁障碍(post-stroke dpression,PSD)患者前额叶氢质子磁共振波谱(Proton magnetic resonance spectroscopy,1H-MRS)的变化特点.方法:应用1H-MRS成像技术检测13例脑卒中后抑郁症患者(PSD组)和20例脑卒中后无抑郁患者(non-PSD组)前额叶N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)3种代谢物
【机 构】
：
南方医科大学珠江医院康复医学科,广东 广州 510282 南方医科大学珠江医院影像诊断科
【出 处】
：
第四届粤港澳台物理医学与康复学学术会议暨2013年广东省医学会物理医学与康复学学术会议
论文部分内容阅读
目的:探讨卒中后抑郁障碍(post-stroke dpression,PSD)患者前额叶氢质子磁共振波谱(Proton magnetic resonance spectroscopy,1H-MRS)的变化特点.
方法:应用1H-MRS成像技术检测13例脑卒中后抑郁症患者(PSD组)和20例脑卒中后无抑郁患者(non-PSD组)前额叶N-乙酰天门冬氨酸(NAA)、胆碱(Cho)、肌酸(Cr)3种代谢物的峰下面积,计算NAA/Cr 和Cho/Cr比值.计量资料根据正态性检验结果,采用两样本t检验或Mann-Whitney U检验及双变量相关分析进行统计分析.
结果:与non-PSD 组比较,PSD 组双侧前额叶Cho/Cr比值显著升高,而左侧前额叶NAA/Cr比值显著下降,右侧前额叶NAA/Cr比值差异无统计学意义.在PSD组中,汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分与左侧前额叶NAA/Cr比值呈显著正相关(P﹤0.05).
结论:PSD患者双侧前额叶的代谢物存在异常,提示其与PSD的发生可能存在密切的关系.同时,左侧前额叶NAA/Cr比值的大小对PSD患者抑郁严重程度的判断有一定的临床价值.
其他文献
目的：观察运动训练联合心理治疗介入在卒中患者康复中的应用效果.方法：将40例卒中后肢体功能障碍并有焦虑或抑郁症状的患者在实施运动训练的同时介入心理治疗,治疗前后分别应用Fugl—Meyer评分表、日常生活自理能力表(Barthel Index)、修改长谷川痴呆量表(HDS)、汉密尔顿焦虑评价量表(Hamilton Anxiety Rating Scale,HAMA)和抑郁评价量表(Hamilton
Background: Previous structural magnetic resonance imaging(MRI) studies in patients with primary major depressive disorder (MDD) have reported changes in several brain areas of the limbic-cortical net
Background: Postoperative pulmonary complications are responsible for significant increases in hospital cost as well as patient morbidity and mortality; respiratory muscle dysfunction represents a con
Background It is well known that physical exercise is beneficial to functional recovery after stroke,but the mechanisms are poorly understood.Transient focal cerebral ischemia induces autophagy,apopto
Object: Many studies suggested that low frequency electromagnetic field (LFEMF) was useful for early healing of wound.Wound healing involve in cutaneous appendage neogenesis such as hair follicle (HF)
Rationale Prcvious studics havc shown that sclective scrotonin reuptake inhibitors,activators of the cortex,apparently improved language functional recoveiy after brain damage rather than simply affec
Purpose: Our previous studies found that epidermal stem cells (ESC) proliferation could be promoted when exposed to 50 Hz electromagnetic fields (EMF) in vitro.In addition,we also found that collagen
目的:研究运动训练对脑梗死大鼠内源性神经干细胞迁移的影响,并观察SDF-1a/CXCR4信号通路在其中的作用.方法：采用线栓法制作成年Wistar大鼠左侧大脑中动脉闭塞再灌注(tMCAO)模型81只,术后随机分成训练组(E,n=18)、训练+AMD3100(AMD3100为SDF-1a/CXCR4 信号通路的特异性阻断剂)组(EA,n=18)、对照组(C,n=18)、对照+AMD3100组(CA,
目的:功能性电刺激(Functional Electrical Stimulation,FES) 在临床上应用广泛,疗效肯定,但具体作用机制尚不明确.本研究选用大鼠作为研究对象,制作急性大脑中动脉阻塞(MiddleCerebral Artery Occlusion,MCAO)模型,对偏瘫侧肢体进行FES 治疗.观察FES 对急性脑梗死大鼠运动功能和梗死侧脑部室管膜下区(Subventricular