【摘 要】
：
To succesfully develop innovative drugs in neuroscience,pharmaceutical researchers cannot limit themselves to classical methods to classify patients and to
【机 构】
：
Translational Medicine Research Centre Singapore Schering-Plough Singapore
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
To succesfully develop innovative drugs in neuroscience,pharmaceutical researchers cannot limit themselves to classical methods to classify patients and to assess clinical efficacy following drug administration.In many cases,a black box exists that leaves many questions unanswered,including diagnosis,prognosis,underlying mechanism,extent of drug exposure and target engagement,and disease.To reveal this black box,drug developers need to follow a rational,data-driven approach.This will result in early selection of both the best candidate medicines and the patient population that is most likely to respond to this drug.Schering-Ploughs translational approach is based on a question-based approach covering early Research to Proof of Concept in man.
其他文献
在环境优美、充满童趣的崇义县城关幼儿园,穿着清爽得体的吴勋华,谈起园里的工作、老师和她的幼儿,嘴角挂着淡淡的微笑,如数家珍,无不流露出她对工作、对事业、对师生、对生
Trk receptor tyrosine kinases have been implicated in cancer and pain.In this talk,the design,synthesis and biological evaluation of a series of 4-aminopyra
Helicobacter pylori colonizes the human stomach of about half of the world population.The colonized individuals may develop gastritis,peptic ulcer,gastric c
曾在中国资本市场上呼风唤雨的资本大鳄正纷纷倒下:唐氏兄弟的「德隆系」、张海、顾雏军……下一个,会是有股市「金手指」之称的南京斯威特集团董事长严晓群吗?
The capital
在广西桂林郊外尧山抗战阵亡将士公墓,安葬着一位为国捐躯的抗日英雄,他就是第五战区第十一集团军第八十四军第一七三师中将师长钟毅。每到清明时节和纪念抗战胜利的日子,人
湘杂六号系湖南省蔬菜研究所选育的晚熟一代杂交茄子 ,１９９９年２月通过湖南省品种审定。该组合植株生长势强 ,株高１０３厘米 ,开展度１００厘米。果直径５ ８ -６厘米 ,单果重２１０ -３５０克。晚熟 ,从定植到采
该品种植株生长势强，根系发达，茎杆粗壮，叶片肥大，叶色浓绿，属中架自封顶类型。株高８０～１００厘米。熟性中早。始花节位６节，主茎３～５花序自封顶。高抗烟草花叶病毒（ＴＭＶ），中抗黄瓜花叶病毒（ＣＭＶ）。皖粉２号在各地
为了探讨草莓“重茬”栽培的可行性 ,１９９５年以来 ,乐亭县徐家店乡农技研究会 ,通过多点连续试验示范 ,终于摸索出棚（室）草莓一栽长两年 ,来年仍高产的经验。据１９９８年４月调查 ,总面积１３３４ （平
巨峰葡萄是目前省内栽培面积较大的优良品种之一。该品种粒大、穗重、味甜、多汁 ,颇受消费者欢迎。该品种适应性强、树势较旺、早熟丰产、定植第二年即可见果、三年６６７ （亩）即可
In the 1920s,methylglyoxal,a keto-aldehyde was widely held as one of the key intermediates of glucose breakdown.But with the elucidation of Embden-Meyerhoff