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Objective: We identified factors associated with early and late postoperative seizure control in patients with supratentorial meningioma plus preoperative seizures.Methods: In this retrospective study, univariate analysis and multivariate logistic re gression analysis compared 24 clinical variables according to the occurrence of early (≤ 1 week) or late (> 1 week) postoperative seizures.Results: Sixty-two of 97 patients (63.9%) were seizure free for the entire postoperative follow-up period (29.5 ± 11.8 months), while 13 patients (13.4%) still had frequent seizures at the end of follow-up.Fourteen of 97 patients (14.4%) experienced early postoperative seizures, and emergence of new postoperative neurological deficits was the only significant risk factor (odds ratio =7.377).Thirty-three patients (34.0%) ex perienced late postoperative seizures at some time during follow-up, including 12 of 14 patients with early postoperative seizures.Associated risk factors for late postopera tive seizures included tumor progression (odds ratio =7.012) and new permanent postoperative neurological deficits (odds ratio =4.327).Conclusion: Occurrence of postoperative seizures in patients with supratentorial menin gioma and preoperative seizure was associated with new postoperative neurological deficits.Reduced cerebral or vascular injury during surgery may lead to fewer post operative neurological deficits and better seizure outcome.