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Invasive aspergillosis (IA) caused principally by Aspergillus fumigatus is associated with high mortality rates in immunocompromised patients.New triazoles (itraconazole and voriconazole) are primary therapies for IA.14--sterol demethylase (cyp51A) codon 98 (cyp51A98) mutations confer resistance to triazoles in A.fumigatus isolates.