High efficient Micro-homologue end-joint(MMEJ)repair of DNA double strand breaks in zebrafish embryo

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：liongliong519

【摘要】

：

【作者】

：

Mudan He Hualin Wang Zuoyan Zhu Yonghua Sun

【机构】

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State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Acade

【出处】

：

第三届全国斑马鱼研究大会

【发表日期】

：

2013年12期

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　　DNA double-strand breaks(DSBs)repair is of great importance for genomic integrity.Homologous recombination(HR)and non-homologous end joining(NHEJ)are recognized as two major mechanistically distinct pathways to repair DSBs.In recent years,an alternative DSBs repair pathway,namely microhomology-mediated end joining(MMEJ),has received increasing attention.MMEJ is believed to utilize a Ku and DNA-PKs independent repair mechanism.

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High efficient Micro-homologue end-joint(MMEJ)repair of DNA double strand breaks in zebrafish embryo

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