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  5. cPKC gamma-mediated UCHL1 downregulation protects cortical neurons against ischemic injuries

cPKC gamma-mediated UCHL1 downregulation protects cortical neurons against ischemic injuries

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：haose1989
【摘 要】
：
Stroke is one of the leading causes of death in the world and many people are currently afflicted with this disease,but there is still lacking effective treatment in clinical practice.Both conventiona
【作 者】
：
Li Zhao Dan Zhang Song Han Shizun Wang Yanlin Luo Junfa Li 
【机 构】
：
Department of Neurobiology and Beijing Institute for Brain Disorders,Capital Medical University,Beij
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
Oxygen-glucose deprivation (OGD) conventional protein kinase C (cPKC)γ ubiquitin 
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　　Stroke is one of the leading causes of death in the world and many people are currently afflicted with this disease,but there is still lacking effective treatment in clinical practice.Both conventional protein kinase C gamma(cPKCγ)and ubiquitin C-terminal hydrolase L1(UCHL1)are neuron specific proteins.We previously reported that cPKCγ participated in neuroprotection against cerebral ischemic injury,and UCHL1 was identified as one of the cPKCγ-interacting proteins.
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