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Introduction: Monoterpenes are non-nutritive dietary components found in the essential oils of citrus fruits and other plants.There are multiple steps within pathways in which dietary components or natural compounds can alter gene expression and phenotypes of cells and thus are therefore molecular targets for chemoprevention.we are exposed to an array of toxins/chemicals that are strong free radical generators.A promising way to control chemical mutagenesis and carcinogenesis is to prevent the formation of reactive metabolites.This study was conducted in rat model of experiment to study the potential of Perillyl alcohol (PA) as a protective agent against 2-AAF induced liver toxicity.Present data indicate that PA has a weakly promoting effect on defence against 2-AAF toxicity.and suggest that PA may be an effective chemopreventive agent for hepatic cancer where there is involvement of reactive oxygen species..Materials &Methods: Eight week old adult male Wistar rats (150-200 g) were obtained from the Central Animal House Facility of Hamdard University, New Delhi.All the chemical used were of highest purity grade.Determination of serum toxicity markers, antioxidant levels involvement of intracellular and extracellular apoptosis pathways of PA induced apoptosis.Results & Discussion: PA attenuates against 2-Acetoaminoflourine (2-AAF) toxicity in hepatic tissue by modulating serum toxicity markers and simultaneous recovery in antioxidant armory.PA may be used against short-term subacute hepatic toxieities as protective agent in cases where there is involvement of oxidative stress and reactive oxygen species.Conclusion: In this study, we evaluated the chemopreventive potential of PA to inhibit toxicity induced by 2-AAF.A 21-day study did not support the PA efficacy as chemopreventive agent but it certainly gives an insight that PA protects the tissue by enhancement of antioxidants and diminution of toxicity markers.